Challenges of Designing Trials for the Primary Prevention of Stroke | Zendy

Philip B. Gorelick | Zendy

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Challenges of Designing Trials for the Primary Prevention of Stroke

Author(s) -

Philip B. Gorelick

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.526947

Subject(s) - medicine , stroke (engine) , clinical trial , primary prevention , context (archaeology) , disease , intensive care medicine , coronary heart disease , secondary prevention , heart disease , clinical endpoint , physical therapy , mechanical engineering , paleontology , engineering , biology

Prevention of a first stroke is an important strategy to reduce morbidity and mortality associated with cerebrovascular disease. In this discussion, we review challenges to development of clinical trials for prevention of a first stroke. Summary of Review- We discuss prevention of first stroke in the context of clinical trial design in the ARRIVE trial and a primary prevention trial in development for the elderly.

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