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MR and CT Monitoring of Recanalization, Reperfusion, and Penumbra Salvage
Author(s) -
Bruno P. Soares,
Jeffrey D. Chien,
Max Wintermark
Publication year - 2008
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.108.526814
Subject(s) - medicine , penumbra , revascularization , collateral circulation , stroke (engine) , acute stroke , reperfusion therapy , blood flow , clinical trial , radiology , cardiology , ischemia , myocardial infarction , tissue plasminogen activator , mechanical engineering , engineering
Revascularization therapies for acute stroke patients aim to rescue the ischemic penumbra by restoring the patency of the occluded artery ("recanalization") and the downstream capillary blood flow ("reperfusion"). This article reviews the definition of recanalization and reperfusion used in stroke clinical trials and their limitations and proposes a study design to determine the relative importance of recanalization, reperfusion, and collateral flow in evaluating the efficacy of revascularization therapies for acute ischemic stroke.

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