Involvement of PTEN Promoter Methylation in Cerebral Cavernous Malformations | Zendy

Yuan Zhu | Zendy; Andreas Wloch | Zendy; Qun Wu | Zendy; Christian Peters | Zendy; Axel Pagenstecher | Zendy; Helmut Bertalanffy | Zendy; Ulrich Sure | Zendy

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Involvement of PTEN Promoter Methylation in Cerebral Cavernous Malformations

Author(s) -

Yuan Zhu,

Andreas Wloch,

Qun Wu,

Christian Peters,

Axel Pagenstecher,

Helmut Bertalanffy,

Ulrich Sure

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.526376

Subject(s) - pten , cancer research , tensin , methylation , dna methylation , microbiology and biotechnology , epigenetics , angiogenesis , biology , medicine , pathology , pi3k/akt/mtor pathway , signal transduction , gene expression , genetics , gene

Cerebral cavernous malformations (CCMs) are prevalent cerebral vascular lesions involving aberrant angiogenesis. However, the underlying mechanism is poorly understood. Phosphatase and tension homolog deleted on chromosome 10 (PTEN), a tumor suppressor, is frequently deficient in various pathologies due to mutation or epigenetic alterations. PTEN promoter hypermethylation is a major epigenetic silencing mechanism leading to activation of angiogenesis in tumors. The present study aimed to investigate whether PTEN promoter methylation was involved in CCMs.

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