Genetic Variation in the Leukotriene Pathway and Carotid Intima-Media Thickness | Zendy

Steve Bevan | Zendy; Matthias Lorenz | Zendy; Matthias Sitzer | Zendy; Hugh S. Markus | Zendy

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Genetic Variation in the Leukotriene Pathway and Carotid Intima-Media Thickness

Author(s) -

Steve Bevan,

Matthias Lorenz,

Matthias Sitzer,

Hugh S. Markus

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.525733

Subject(s) - intima media thickness , medicine , leukotriene , stroke (engine) , cardiology , genetic variation , population , pathology , carotid arteries , endocrinology , mechanical engineering , environmental health , asthma , engineering

The recent finding that genetic variation in the leukotriene biosynthesis pathway may confer an increased risk of ischemic stroke and atherosclerosis has implicated the leukotriene family as potential mediators of cardiovascular disease. Using a 2-stage replication design, we have examined whether polymorphisms in 8 genes related to this pathway are associated with early atherosclerosis and remodeling as measured by carotid artery intima-media thickness.

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