Good Laboratory Practice | Zendy

Malcolm Macleod | Zendy; Marc Fisher | Zendy; Victoria O’Collins | Zendy; Emily S. Sena | Zendy; Ulrich Dirnagl | Zendy; Philip M. Bath | Zendy; Alastair M. Buchan | Zendy; H. Bart van der Worp | Zendy; Richard J. Traystman | Zendy; Kazuo Minematsu | Zendy; Geoffrey A. Donnan | Zendy; David W. Howells | Zendy

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Good Laboratory Practice

Author(s) -

Malcolm Macleod,

Marc Fisher,

Victoria O’Collins,

Emily S. Sena,

Ulrich Dirnagl,

Philip M. Bath,

Alastair M. Buchan,

H. Bart van der Worp,

Richard J. Traystman,

Kazuo Minematsu,

Geoffrey A. Donnan,

David W. Howells

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.525386

Subject(s) - medicine , stroke (engine) , neuroprotection , human studies , animal model , intensive care medicine , outcome (game theory) , research design , set (abstract data type) , medical physics , pharmacology , mechanical engineering , mathematics , mathematical economics , engineering , social science , sociology , computer science , programming language

As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review- Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy.

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