Acute Vascular Disruption and Aquaporin 4 Loss After Stroke | Zendy

Beth Friedman | Zendy; Christian Schachtrup | Zendy; Philbert S. Tsai | Zendy; Andy Y. Shih | Zendy; Katerina Akassoglou | Zendy; David Kleinfeld | Zendy; Patrick D. Lyden | Zendy

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Acute Vascular Disruption and Aquaporin 4 Loss After Stroke

Author(s) -

Beth Friedman,

Christian Schachtrup,

Philbert S. Tsai,

Andy Y. Shih,

Katerina Akassoglou,

David Kleinfeld,

Patrick D. Lyden

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.523720

Subject(s) - aquaporin 4 , fluorescein , propidium iodide , glial fibrillary acidic protein , medicine , fluorescein isothiocyanate , microbiology and biotechnology , astrocyte , pathology , endocrinology , programmed cell death , apoptosis , biology , immunohistochemistry , biochemistry , central nervous system , fluorescence , physics , quantum mechanics

Ischemic protection has been demonstrated by a decrease in stroke-infarct size in transgenic mice with deficient Aquaporin 4 (AQP4) expression. However, it is not known whether AQP4 is rapidly reduced during acute stroke in animals with normal AQP4 phenotype, which may provide a potential self-protective mechanism.

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