Cerebral Blood Flow Measurement in Children With Sickle Cell Disease Using Continuous Arterial Spin Labeling at 3.0-Tesla MRI | Zendy

Xandra W. van den Tweel | Zendy; Aart J. Nederveen | Zendy; Charles B.L.M. Majoie | Zendy; Johanna H. van der Lee | Zendy; L.J.J.C. Wagener-Schimmel | Zendy; Marianne A.A. van Walderveen | Zendy; Bwee Tien Poll The | Zendy; Paul J. Nederkoorn | Zendy; Harriët Heijboer | Zendy; Karin Fijnvandraat | Zendy

Open Access

Cerebral Blood Flow Measurement in Children With Sickle Cell Disease Using Continuous Arterial Spin Labeling at 3.0-Tesla MRI

Author(s) -

Xandra W. van den Tweel,

Aart J. Nederveen,

Charles B.L.M. Majoie,

Johanna H. van der Lee,

L.J.J.C. Wagener-Schimmel,

Marianne A.A. van Walderveen,

Bwee Tien Poll The,

Paul J. Nederkoorn,

Harriët Heijboer,

Karin Fijnvandraat

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.523308

Subject(s) - medicine , arterial spin labeling , cerebral blood flow , magnetic resonance imaging , stroke (engine) , blood flow , cardiology , nuclear magnetic resonance , pathology , radiology , mechanical engineering , physics , engineering

Cerebral infarction is an important complication of sickle cell disease (SCD) and occurs in one third of the patients with SCD. The risk of infarction is commonly attributed to the hyperemia that is associated with anemia and reduces the cerebral vascular reserve. We measured regional cerebral blood flow (rCBF) by continuous arterial spin labeling MRI, which is a noninvasive method that does not require ionizing radiation. The purpose of this study was to examine rCBF in children with SCD and compare it with rCBF in healthy children.

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