Genome Screen to Detect Linkage to Common Susceptibility Genes for Intracranial and Aortic Aneurysms | Zendy

Bradford B. Worrall | Zendy; Tatiana Foroud | Zendy; Robert D. Brown | Zendy; E. Sander Connolly | Zendy; Richard Hornung | Zendy; John Huston | Zendy; Dawn Kleindorfer | Zendy; Daniel L. Koller | Zendy; Dongbing Lai | Zendy; Charles J. Moomaw | Zendy; Laura Sauerbeck | Zendy; Daniel Woo | Zendy; Joseph P. Broderick | Zendy

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Genome Screen to Detect Linkage to Common Susceptibility Genes for Intracranial and Aortic Aneurysms

Author(s) -

Bradford B. Worrall,

Tatiana Foroud,

Robert D. Brown,

E. Sander Connolly,

Richard Hornung,

John Huston,

Dawn Kleindorfer,

Daniel L. Koller,

Dongbing Lai,

Charles J. Moomaw,

Laura Sauerbeck,

Daniel Woo,

Joseph P. Broderick

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.522631

Subject(s) - medicine , genetic linkage , locus (genetics) , odds ratio , genetics , genome wide association study , gene , genotype , single nucleotide polymorphism , biology

Risk for both intracranial aneurysms (IAs) and aortic aneurysms (AAs) is thought to be heritable with mounting evidence for genetic predisposition. The concept of shared risk for these conditions is challenged by differences in age of diagnosis and demographic characteristics. We performed a genomewide linkage analysis in multiplex families with both IA and AA from the Familial Intracranial Aneurysm study.

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