Abnormal Responses of the Human Cerebral Microcirculation to Papaverin During Aneurysm Surgery | Zendy

Frederik A. Pennings | Zendy; K. W. Albrecht | Zendy; J. Paul Muizelaar | Zendy; P. Richard Schuurman | Zendy; Gerrit J. Bouma | Zendy

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Abnormal Responses of the Human Cerebral Microcirculation to Papaverin During Aneurysm Surgery

Author(s) -

Frederik A. Pennings,

K. W. Albrecht,

J. Paul Muizelaar,

P. Richard Schuurman,

Gerrit J. Bouma

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.522375

Subject(s) - medicine , microcirculation , aneurysm , cerebrovascular circulation , cardiology , surgery , cerebral blood flow

The role of the cerebral microcirculation in delayed ischemia after subarachnoid hemorrhage remains obscure. To test the hypothesis that cerebral arterioles have a reduced capacity to dilate after subarachnoid hemorrhage, we studied the microvascular responses to papaverine (PPV) in patients undergoing aneurysm surgery. Method- In 14 patients undergoing aneurysm surgery, the diameter changes of cortical microvessels after topical application of PPV were observed using orthogonal polarizing spectral imaging.

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