Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance | Zendy

Min Chen | Zendy; TingJia Lu | Zendy; Xiaojing Chen | Zendy; Yang Zhou | Zendy; Chen Qian | Zendy; Xiaoyan Feng | Zendy; Li Xu | Zendy; Wenhu Duan | Zendy; ZhiQi Xiong | Zendy

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Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance

Author(s) -

Min Chen,

TingJia Lu,

Xiaojing Chen,

Yang Zhou,

Chen Qian,

Xiaoyan Feng,

Li Xu,

Wenhu Duan,

ZhiQi Xiong

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.521898

Subject(s) - medicine , nmda receptor , ischemic stroke , ischemia , ischemic injury , stroke (engine) , neuroscience , receptor , ischemic preconditioning , programmed cell death , cardiology , apoptosis , biochemistry , biology , mechanical engineering , chemistry , engineering

Activation of NMDA subtypes of glutamate receptors is implicated in cell damage induced by ischemia as well as for the establishment of ischemic tolerance after ischemic preconditioning in animal models. We investigated the contributions of NR2A- and NR2B-containing NMDA receptors to ischemic cell death and ischemic tolerance in a rat model of transient global ischemia.

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