Comparison of Methods for Magnetic Resonance-Guided [18-F]Fluorodeoxyglucose Positron Emission Tomography in Human Carotid Arteries | Zendy

David IzquierdoGarcia | Zendy; John R. Davies | Zendy; Martin J. Graves | Zendy; James H.F. Rudd | Zendy; Jonathan H. Gillard | Zendy; Peter L. Weissberg | Zendy; Tim D. Fryer | Zendy; Elizabeth A. Warburton | Zendy

Open Access

Comparison of Methods for Magnetic Resonance-Guided [18-F]Fluorodeoxyglucose Positron Emission Tomography in Human Carotid Arteries

Author(s) -

David IzquierdoGarcia,

John R. Davies,

Martin J. Graves,

James H.F. Rudd,

Jonathan H. Gillard,

Peter L. Weissberg,

Tim D. Fryer,

Elizabeth A. Warburton

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.521393

Subject(s) - medicine , intraclass correlation , nuclear medicine , positron emission tomography , magnetic resonance imaging , reproducibility , standardized uptake value , fluorodeoxyglucose , carotid arteries , gold standard (test) , radiology , clinical psychology , statistics , mathematics , psychometrics

Inflammation is a major risk factor for atherosclerotic plaque rupture and clinical events. Previous studies have shown that plaque [(18)F]fluorodeoxyglucose (FDG) uptake correlates with macrophage content. In this study we examined the reproducibility of 3 methods of quantifying plaque FDG uptake in the carotid arteries using positron emission tomography (PET). The correlation between 2 simplified uptake parameters (standardized uptake value [SUV], vessel wall-to-blood ratio [VBR]) and a gold standard technique (influx rate [K(i)]) was also determined. We used MRI to correct carotid plaque FDG uptake for partial volume error.

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