Exaggeration of Focal Cerebral Ischemia in Transgenic Mice Carrying Human Renin and Human Angiotensinogen Genes | Zendy

Shinji Inaba | Zendy; Masaru Iwai | Zendy; Yumiko Tomono | Zendy; Izumi Senba | Zendy; Megumi Furuno | Zendy; Harumi Kanno | Zendy; Hideki Okayama | Zendy; Masaki Mogi | Zendy; Jitsuo Higaki | Zendy; Masatsugu Horiuchi | Zendy

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Exaggeration of Focal Cerebral Ischemia in Transgenic Mice Carrying Human Renin and Human Angiotensinogen Genes

Author(s) -

Shinji Inaba,

Masaru Iwai,

Yumiko Tomono,

Izumi Senba,

Megumi Furuno,

Harumi Kanno,

Hideki Okayama,

Masaki Mogi,

Jitsuo Higaki,

Masatsugu Horiuchi

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.519801

Subject(s) - medicine , renin–angiotensin system , exaggeration , ischemia , genetically modified mouse , gene , transgene , endocrinology , genetics , psychiatry , biology , blood pressure

We examined the possibility that activation of the human brain renin-angiotensin system is involved in enhancement of ischemic brain damage using chimeric transgenic mice with human renin (hRN) and human angiotensinogen (hANG) genes.

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