Allopurinol Use Yields Potentially Beneficial Effects on Inflammatory Indices in Those With Recent Ischemic Stroke | Zendy

Scott Muir | Zendy; Craig Harrow | Zendy; Jesse Dawson | Zendy; Kennedy R. Lees | Zendy; Christopher J. Weir | Zendy; Naveed Sattar | Zendy; Matthew R. Walters | Zendy

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Allopurinol Use Yields Potentially Beneficial Effects on Inflammatory Indices in Those With Recent Ischemic Stroke

Author(s) -

Scott Muir,

Craig Harrow,

Jesse Dawson,

Kennedy R. Lees,

Christopher J. Weir,

Naveed Sattar,

Matthew R. Walters

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.519793

Subject(s) - allopurinol , medicine , uric acid , placebo , tolerability , stroke (engine) , xanthine oxidase , hyperuricemia , gastroenterology , pharmacology , anesthesia , surgery , adverse effect , pathology , biochemistry , mechanical engineering , chemistry , alternative medicine , engineering , enzyme

Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke. The xanthine oxidase inhibitor allopurinol lowers uric acid but also attenuates expression of inflammatory adhesion molecules in murine models, reduces oxidative stress in the vasculature, and improves endothelial function. We sought to investigate whether allopurinol alters expression of inflammatory markers after acute ischemic stroke.

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