Experimental Model of Warfarin-Associated Intracerebral Hemorrhage | Zendy

Christian Foerch | Zendy; Ken Arai | Zendy; Guang Jin | Zendy; KyungPil Park | Zendy; Stefanie Pallast | Zendy; Klaus van Leyen | Zendy; Eng H. Lo | Zendy

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Experimental Model of Warfarin-Associated Intracerebral Hemorrhage

Author(s) -

Christian Foerch,

Ken Arai,

Guang Jin,

KyungPil Park,

Stefanie Pallast,

Klaus van Leyen,

Eng H. Lo

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.517482

Subject(s) - medicine , warfarin , intracerebral hemorrhage , atrial fibrillation , hematoma , anesthesia , stroke (engine) , gastroenterology , cardiology , surgery , glasgow coma scale , mechanical engineering , engineering

Future demographic changes predict an increase in the number of patients with atrial fibrillation. As long-term anticoagulation for the prevention of ischemic strokes becomes more prevalent, the burden of warfarin-associated intracerebral hemorrhage (W-ICH) is likely to grow. However, little is known about the clinical aspects and pathophysiologic mechanisms of W-ICH. This study describes the development of a mouse model of W-ICH in which hematoma growth and outcomes can be correlated with anticoagulation parameters.

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