A Dual Role of the NF-κB Pathway in Neonatal Hypoxic-Ischemic Brain Damage | Zendy

Cora H. Nijboer | Zendy; Cobi J. Heijnen | Zendy; Floris Groenendaal | Zendy; Michael J. May | Zendy; Frank van Bel | Zendy; Annemieke Kavelaars | Zendy

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A Dual Role of the NF-κB Pathway in Neonatal Hypoxic-Ischemic Brain Damage

Author(s) -

Cora H. Nijboer,

Cobi J. Heijnen,

Floris Groenendaal,

Michael J. May,

Frank van Bel,

Annemieke Kavelaars

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.516401

Subject(s) - medicine , neuroprotection , downregulation and upregulation , hypoxia (environmental) , brain damage , in vivo , pharmacology , apoptosis , nf κb , ischemia , cytokine , inflammation , biology , chemistry , biochemistry , microbiology and biotechnology , organic chemistry , oxygen , gene

NF-kappaB is a transcription factor that regulates inflammatory and apoptotic pathways. We described previously that intraperitoneal administration of the NF-kappaB inhibitor TAT-NBD at 0 and 3 hours after neonatal hypoxia-ischemia (HI) markedly reduced brain damage. We hypothesize that timing and duration of NF-kappaB inhibition will be a major factor in determining outcome.

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