Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality | Zendy

Malcolm Macleod | Zendy; H. Bart van der Worp | Zendy; Emily S. Sena | Zendy; David W. Howells | Zendy; Ulrich Dirnagl | Zendy; Geoffrey A. Donnan | Zendy

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Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

Author(s) -

Malcolm Macleod,

H. Bart van der Worp,

Emily S. Sena,

David W. Howells,

Ulrich Dirnagl,

Geoffrey A. Donnan

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.515957

Subject(s) - medicine , stroke (engine) , clinical trial , randomization , meta analysis , animal studies , quality (philosophy) , human studies , intensive care medicine , mechanical engineering , engineering , philosophy , epistemology

The neutral results of the SAINT II trial have again highlighted difficulties translating neuroprotective efficacy from bench to bedside. Animal studies are susceptible to study quality biases, which may lead to overstatement of efficacy. We report the impact of study quality on published estimates of the efficacy of NXY-059 in animal models of stroke.

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