Vinpocetine for Acute Ischemic Stroke | Zendy

Dániel Bereczki | Zendy; István Fekete | Zendy

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Vinpocetine for Acute Ischemic Stroke

Author(s) -

Dániel Bereczki,

István Fekete

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.514174

Subject(s) - medicine , vinpocetine , stroke (engine) , ischemic stroke , acute stroke , cardiology , ischemia , pharmacology , tissue plasminogen activator , mechanical engineering , engineering

Graeme J. Hankey MD, FRCP Section Editor: Vinpocetine, a vasoactive vinca alkaloid, is claimed to be a neuroprotectant due to its sodium and calcium channel blocker and antioxidant effects. Vinpocetine decreased the size of cerebral infarction after middle cerebral artery occlusion in rats and mice. In controlled human studies, vinpocetine increased cerebral perfusion and oxygen extraction and prevented the worsening of attention in patients with multiple cerebral infarcts. Vinpocetine has been used to treat stroke in several countries in Europe (eg, Hungary, Poland, Germany, and Russia) and in Asia (eg, China and Japan). ObjectiveThe objective of this study was to determine if vinpocetine treatment decreases the rate of early (within 1 month) and late (between 3 and 6 months) case fatality and …

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