Hematopoietic Stem Cells Reduce Postischemic Inflammation and Ameliorate Ischemic Brain Injury | Zendy

Sönke Schwarting | Zendy; Sara A. Litwak | Zendy; Wenlin Hao | Zendy; Mathias Bähr | Zendy; Jens Weise | Zendy; Harald Neumann | Zendy

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Hematopoietic Stem Cells Reduce Postischemic Inflammation and Ameliorate Ischemic Brain Injury

Author(s) -

Sönke Schwarting,

Sara A. Litwak,

Wenlin Hao,

Mathias Bähr,

Jens Weise,

Harald Neumann

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.513978

Subject(s) - medicine , inflammation , haematopoiesis , stem cell , spleen , bone marrow , proinflammatory cytokine , immune system , neuroprotection , chemokine , microglia , pathology , ischemia , neural stem cell , immunology , microbiology and biotechnology , pharmacology , biology

Systemic injection of hematopoietic stem cells after ischemic cardiac or neural lesions is one approach to promote tissue repair. However, mechanisms of possible protective or reparative effects are poorly understood. In this study we analyzed the effect of lineage-negative bone marrow-derived hematopoietic stem and precursor cells (Lin(-)-HSCs) on ischemic brain injury in mice.

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