Homocysteine and Its Relationship to Stroke Subtypes in a UK Black Population | Zendy

Usman Khan | Zendy; Carollyn Crossley | Zendy; Lalit Kalra | Zendy; Anthony G. Rudd | Zendy; Charles Wolfe | Zendy; Paul Collinson | Zendy; Hugh S. Markus | Zendy

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Homocysteine and Its Relationship to Stroke Subtypes in a UK Black Population

Author(s) -

Usman Khan,

Carollyn Crossley,

Lalit Kalra,

Anthony G. Rudd,

Charles Wolfe,

Paul Collinson,

Hugh S. Markus

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.513416

Subject(s) - medicine , stroke (engine) , homocysteine , population , gerontology , environmental health , mechanical engineering , engineering

Homocysteine is an endothelial toxin and elevated levels have been associated with stroke risk. Stroke, particularly the small vessel disease (SVD) subtype, is increased in U.S. and UK black populations. In white populations elevated homocysteine has been associated with SVD, especially confluent leukoaraiosis, and may be acting through endothelial dysfunction. We determined the association between homocysteine and stroke subtypes, especially SVD, in a well-phenotyped UK cohort of black stroke patients compared to community controls.

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