Blood Cell-Derived RANTES Mediates Cerebral Microvascular Dysfunction, Inflammation, and Tissue Injury After Focal Ischemia–Reperfusion | Zendy

Satoshi Terao | Zendy; Gökhan Yılmaz | Zendy; Karen Y. Stokes | Zendy; Janice Russell | Zendy; Mami Ishikawa | Zendy; Takeshi Kawase | Zendy; D. Neil Granger | Zendy

Open Access

Blood Cell-Derived RANTES Mediates Cerebral Microvascular Dysfunction, Inflammation, and Tissue Injury After Focal Ischemia–Reperfusion

Author(s) -

Satoshi Terao,

Gökhan Yılmaz,

Karen Y. Stokes,

Janice Russell,

Mami Ishikawa,

Takeshi Kawase,

D. Neil Granger

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.513150

Subject(s) - medicine , ischemia , chemokine , reperfusion injury , inflammation , blood–brain barrier , middle cerebral artery , cytokine , pathology , central nervous system , immunology

Although chemokines have been implicated in cardiovascular diseases, few studies have addressed the role of these inflammatory mediators in ischemic stroke. This study tested the hypothesis that RANTES (CCL5; regulated on activation, normal T-cell expressed and secreted) mediates the cerebral microvascular dysfunction, inflammation, and tissue injury induced by brain ischemia and reperfusion.

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