Tissue Microstructural Changes Are Independently Associated With Cognitive Impairment in Cerebral Amyloid Angiopathy | Zendy

Anand Viswanathan | Zendy; Pratik Patel | Zendy; Rosanna Rahman | Zendy; R. N. Kaveer Nandigam | Zendy; Catherine Kinnecom | Zendy; Luc Bracoud | Zendy; Jonathan Rosand | Zendy; Hugues Chabriat | Zendy; Steven M. Greenberg | Zendy; Eric E. Smith | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Tissue Microstructural Changes Are Independently Associated With Cognitive Impairment in Cerebral Amyloid Angiopathy

Author(s) -

Anand Viswanathan,

Pratik Patel,

Rosanna Rahman,

R. N. Kaveer Nandigam,

Catherine Kinnecom,

Luc Bracoud,

Jonathan Rosand,

Hugues Chabriat,

Steven M. Greenberg,

Eric E. Smith

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.509091

Subject(s) - hyperintensity , medicine , cerebral amyloid angiopathy , intracerebral hemorrhage , diffusion mri , white matter , cardiology , atrophy , cognitive impairment , pathology , magnetic resonance imaging , cognitive decline , cognition , dementia , radiology , psychiatry , subarachnoid hemorrhage , disease

Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage and cognitive impairment and is associated with white matter hyperintensities and cerebral microbleeds. MRI diffusion tensor imaging detects microstructural tissue damage in advanced CAA even in areas that appear normal on conventional MRI. We hypothesized that higher global mean apparent diffusion coefficient (mean ADC), reflecting a higher amount of chronic tissue disruption caused by CAA, would be independently associated with CAA-related cognitive impairment.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research