Nogo-A Expression After Focal Ischemic Stroke in the Adult Rat | Zendy

Joseph L. Cheatwood | Zendy; April J. Emerick | Zendy; Martin E. Schwab | Zendy; Gwendolyn L. Kartje | Zendy

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Nogo-A Expression After Focal Ischemic Stroke in the Adult Rat

Author(s) -

Joseph L. Cheatwood,

April J. Emerick,

Martin E. Schwab,

Gwendolyn L. Kartje

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.507426

Subject(s) - medicine , ischemic stroke , stroke (engine) , ischemia , cardiology , pathology , mechanical engineering , engineering

The Nogo-A protein is an important inhibitor of axonal remodeling after central nervous system injuries, including ischemic stroke. Interfering with the function of Nogo-A via infusion of a therapeutic anti-Nogo-A antibody after stroke increases neuronal remodeling and enhances functional recovery in rats. In this study, we describe the regional distribution of cortical neurons expressing Nogo-A in normal rats and following middle cerebral artery occlusion (MCAO).

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