Polymorphisms in Platelet Glycoprotein 1bα and Factor VII and Risk of Ischemic Stroke | Zendy

Jane Maguire | Zendy; Ammarin Thakkinstian | Zendy; Jon Sturm | Zendy; Christopher Levi | Zendy; Lisa F. Lincz | Zendy; Mark Parsons | Zendy; Scott Whyte | Zendy; John Attia | Zendy

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Polymorphisms in Platelet Glycoprotein 1bα and Factor VII and Risk of Ischemic Stroke

Author(s) -

Jane Maguire,

Ammarin Thakkinstian,

Jon Sturm,

Christopher Levi,

Lisa F. Lincz,

Mark Parsons,

Scott Whyte,

John Attia

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.507228

Subject(s) - medicine , ischemic stroke , stroke (engine) , risk factor , glycoprotein , platelet , platelet membrane glycoprotein , cardiology , ischemia , genetics , mechanical engineering , biology , engineering

Platelets and components of the coagulation cascade are known to be instrumental in the pathogenesis of arterial occlusive disorders. The aim of this meta-analysis is to test the hypothesis that genetic variation in the platelet glycoprotein 1balpha and Factor VII genes influence the occurrence of ischemic stroke. All genetic association studies that examined the R353Q (rs6046) polymorphism of the Factor VII gene and 2 polymorphisms of the platelet glycoprotein (1balpha) gene (Thr/Met rs6065 and Kozak sequence -5 C/T rs2243093) in relation to ischemic stroke were examined.

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