Dopamine D1-Like Receptors Depress Excitatory Synaptic Transmissions in Striatal Neurons After Transient Forebrain Ischemia | Zendy

Yuchun Zhang | Zendy; Ping Deng | Zendy; Yiwen Ruan | Zendy; Zao C. Xu | Zendy

Open Access

Dopamine D1-Like Receptors Depress Excitatory Synaptic Transmissions in Striatal Neurons After Transient Forebrain Ischemia

Author(s) -

Yuchun Zhang,

Ping Deng,

Yiwen Ruan,

Zao C. Xu

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.506824

Subject(s) - excitatory postsynaptic potential , dopamine , neurotransmission , neuroscience , ischemia , medicine , striatum , agonist , medium spiny neuron , dopamine receptor d1 , dopamine receptor , biology , receptor

Spiny neurons in the neostriatum are highly vulnerable to ischemia. Despite an enormous body of research suggesting that dopamine is involved in ischemia-induced neuronal loss in the striatum, it remains unclear how dopamine interacts with the glutamatergic excitotoxicity that is widely accepted as a major cause of ischemic cell death. Our study was designed to investigate the effects of dopamine D1 receptor (D1R) activation on excitatory neurotransmission in postischemic striatal neurons.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research