Meta-Analysis of the Efficacy of Granulocyte-Colony Stimulating Factor in Animal Models of Focal Cerebral Ischemia | Zendy

Jens Minnerup | Zendy; Jan Heidrich | Zendy; Jürgen Wellmann | Zendy; Andreas Rogalewski | Zendy; Armin Schneider | Zendy; WolfRüdiger Schäbitz | Zendy

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Meta-Analysis of the Efficacy of Granulocyte-Colony Stimulating Factor in Animal Models of Focal Cerebral Ischemia

Author(s) -

Jens Minnerup,

Jan Heidrich,

Jürgen Wellmann,

Andreas Rogalewski,

Armin Schneider,

WolfRüdiger Schäbitz

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.506816

Subject(s) - medicine , hematopoietic growth factor , granulocyte colony stimulating factor , stroke (engine) , animal studies , ischemia , clinical trial , infarction , meta analysis , anesthesia , haematopoiesis , chemotherapy , myocardial infarction , mechanical engineering , genetics , stem cell , engineering , biology

Recent reports have described the efficacy of the hematopoietic growth factor granulocyte-colony stimulating factor (G-CSF) in animal stroke models. Early clinical multicenter trials evaluating the effect of G-CSF in acute stroke and pilot clinical trials for the subacute phase are ongoing. To guide further development, a meta-analysis was performed to assess the effects of G-CSF on infarct size and sensorimotor deficits.

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