Targeted Disruption of Hsp110/105 Gene Protects Against Ischemic Stress | Zendy

Junji Nakamura | Zendy; Motoaki Fujimoto | Zendy; Kunihiko Yasuda | Zendy; Kiyoshi Takeda | Zendy; Shizuo Akira | Zendy; Takumi Hatayama | Zendy; Yasushi Takagi | Zendy; Kazuhiko Nozaki | Zendy; Nobuko Hosokawa | Zendy; Kazuhiro Nagata | Zendy

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Targeted Disruption of Hsp110/105 Gene Protects Against Ischemic Stress

Author(s) -

Junji Nakamura,

Motoaki Fujimoto,

Kunihiko Yasuda,

Kiyoshi Takeda,

Shizuo Akira,

Takumi Hatayama,

Yasushi Takagi,

Kazuhiko Nozaki,

Nobuko Hosokawa,

Kazuhiro Nagata

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.506188

Subject(s) - hsp70 , medicine , heat shock protein , ischemia , chaperone (clinical) , in vivo , pathology , biology , gene , biochemistry , genetics

Hsp110/105 belongs to the HSP110 heat shock protein family, which is a subgroup of the HSP70 family. In mammals, Hsp110/105 is constitutively expressed but exhibits particularly high levels in the brain. It has recently been shown that both Hsp110/105 and Hsp70 are elevated after cerebral ischemia. To study the physiological role of this protein in vivo, we generated hsp110/105 knockout (KO) mice and investigate the effect of reduced Hsp110/105 levels on focal cerebral ischemia.

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