Effectiveness of PSD95 Inhibitors in Permanent and Transient Focal Ischemia in the Rat | Zendy

HongShuo Sun | Zendy; Tracy A. Doucette | Zendy; Yitao Liu | Zendy; Yuan Fang | Zendy; Lucy Teves | Zendy; Michelle Aarts | Zendy; Catherine L. Ryan | Zendy; Paul B. Bernard | Zendy; Anthony Lau | Zendy; Joan P. Forder | Zendy; Michael W. Salter | Zendy; Yu Tian Wang | Zendy; R. Andrew Tasker | Zendy; Michael Tymianski | Zendy

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Effectiveness of PSD95 Inhibitors in Permanent and Transient Focal Ischemia in the Rat

Author(s) -

HongShuo Sun,

Tracy A. Doucette,

Yitao Liu,

Yuan Fang,

Lucy Teves,

Michelle Aarts,

Catherine L. Ryan,

Paul B. Bernard,

Anthony Lau,

Joan P. Forder,

Michael W. Salter,

Yu Tian Wang,

R. Andrew Tasker,

Michael Tymianski

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.506048

Subject(s) - medicine , middle cerebral artery , occlusion , postsynaptic potential , postsynaptic density , stroke (engine) , ischemia , anesthesia , excitatory postsynaptic potential , neuroprotection , cerebral arteries , cardiology , inhibitory postsynaptic potential , mechanical engineering , receptor , engineering

Postsynaptic density-95 inhibitors reduce ischemic brain damage without inhibiting excitatory neurotransmission, circumventing the negative consequences of glutamatergic inhibition. However, their efficacy in permanent ischemia and in providing permanent neuroprotection and neurobehavioral improvement in a practical therapeutic window is unproven. These were tested here under conditions that included fever, which is a common occurrence in clinical stroke.

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