Early Disruption of the Blood–Brain Barrier After Thrombolytic Therapy Predicts Hemorrhage in Patients With Acute Stroke | Zendy

Andreas Kastrup | Zendy; Klaus Gröschel | Zendy; Thomas Ringer | Zendy; Christoph Redecker | Zendy; Robert Cordesmeyer | Zendy; Otto W. Witte | Zendy; Christoph Terborg | Zendy

Open Access

Early Disruption of the Blood–Brain Barrier After Thrombolytic Therapy Predicts Hemorrhage in Patients With Acute Stroke

Author(s) -

Andreas Kastrup,

Klaus Gröschel,

Thomas Ringer,

Christoph Redecker,

Robert Cordesmeyer,

Otto W. Witte,

Christoph Terborg

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.505420

Subject(s) - medicine , thrombolysis , interquartile range , tissue plasminogen activator , stroke (engine) , blood–brain barrier , parenchyma , magnetic resonance imaging , perfusion scanning , intracerebral hemorrhage , pathology , surgery , perfusion , radiology , cardiology , central nervous system , myocardial infarction , subarachnoid hemorrhage , mechanical engineering , engineering

Leaks of the blood-brain barrier can be detected on postcontrast-enhanced T1-weighted MRIs. Although early disruptions of the blood-brain barrier appear to be an important risk factor for tissue plasminogen activator-related hemorrhages in rodents, little is known about their incidence and consequences in human stroke.

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