Common CCR5-del32 Frameshift Mutation Associated With Serum Levels of Inflammatory Markers and Cardiovascular Disease Risk in the Bruneck Population | Zendy

Ali R. Afzal | Zendy; Stefan Kiechl | Zendy; Yousef Daryani | Zendy; Arusha Weerasinghe | Zendy; Yang Zhang | Zendy; Markus Reindl | Zendy; Agnes Mayr | Zendy; Siegfried Weger | Zendy; Qingbo Xu | Zendy; Johann Willeit | Zendy

Open Access

Common CCR5-del32 Frameshift Mutation Associated With Serum Levels of Inflammatory Markers and Cardiovascular Disease Risk in the Bruneck Population

Author(s) -

Ali R. Afzal,

Stefan Kiechl,

Yousef Daryani,

Arusha Weerasinghe,

Yang Zhang,

Markus Reindl,

Agnes Mayr,

Siegfried Weger,

Qingbo Xu,

Johann Willeit

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.504381

Subject(s) - medicine , frameshift mutation , disease , population , mutation , atherosclerotic cardiovascular disease , stroke (engine) , genetics , gene , environmental health , biology , mechanical engineering , engineering

Atherosclerosis is a progressive inflammatory disease and can develop in large arteries such as carotid and femoral arteries or medium-sized muscular arteries of the heart. Previous predominantly experimental studies suggested an important role of chemokines in the development of atherosclerosis. The main aim of this study was to examine potential effect of the CCR5-del32 mutation on systemic inflammation, intima-media thickness in carotid and femoral arteries, and on the indices of cardiovascular disease.

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