Filamentous Middle Cerebral Artery Occlusion Causes Ischemic Damage to the Retina in Mice | Zendy

Ernest C. Steele | Zendy; Qingmin Guo | Zendy; Shobu Namura | Zendy

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Filamentous Middle Cerebral Artery Occlusion Causes Ischemic Damage to the Retina in Mice

Author(s) -

Ernest C. Steele,

Qingmin Guo,

Shobu Namura

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.504357

Subject(s) - medicine , retina , ischemia , cresyl violet , retinal , optic nerve , perfusion , reperfusion injury , occlusion , retinal ganglion cell , stroke (engine) , isoflurane , pathology , anesthesia , ophthalmology , staining , biology , neuroscience , mechanical engineering , engineering

Filamentous middle cerebral artery occlusion (fMCAO) is the most frequently used focal cerebral ischemia model in rodents. The proximity of the ophthalmic artery to the middle cerebral artery suggests that fMCAO induces retinal ischemia. We therefore tested whether fMCAO induces ischemia/reperfusion damage in retina in mice.

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