Open AccessSimvastatin Suppresses the Progression of Experimentally Induced Cerebral Aneurysms in Rats
Author(s) -
Tomohiro Aoki,
Hiroharu Kataoka,
Ryota Ishibashi,
Kazuhiko Nozaki,
Nobuo Hashimoto
Publication year - 2008
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.107.503086
Subject(s) - simvastatin , medicine , nitric oxide synthase , nitric oxide , matrix metalloproteinase , statin , cell adhesion molecule , endocrinology , immunology
The pathophysiology of cerebral aneurysms (CAs) is linked to chronic inflammation and degradation of extracellular matrix in vascular walls. Because statins have protective effects on various vascular diseases independent of their lipid-lowering effects, we investigated the effect of simvastatin on CA progression.
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