Whole Genome Analyses Suggest Ischemic Stroke and Heart Disease Share an Association With Polymorphisms on Chromosome 9p21 | Zendy

Mar Matarín | Zendy; W. Mark Brown | Zendy; Andrew Singleton | Zendy; John Hardy | Zendy; James F. Meschia | Zendy

Open Access

Whole Genome Analyses Suggest Ischemic Stroke and Heart Disease Share an Association With Polymorphisms on Chromosome 9p21

Author(s) -

Mar Matarín,

W. Mark Brown,

Andrew Singleton,

John Hardy,

James F. Meschia

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.502963

Subject(s) - medicine , ischemic stroke , genome wide association study , stroke (engine) , disease , chromosome , genetics , genome , genetic association , cardiology , gene , single nucleotide polymorphism , genotype , ischemia , biology , mechanical engineering , engineering

Recently independent studies reported an association between coronary heart disease and single-nucleotide polymorphisms (SNPs) located at chromosome 9p21, near CDKN2A and CDKN2B genes. Given that stroke is a common complication after myocardial infarction, we investigated if the same SNPs were associated with ischemic stroke in our population.

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