The Continued Yin and Yang of Uric Acid

To the Editor:We read with interest the recent research letter by Amaro et al.1 Their analysis adds to the growing literature on uric acid (UA) and vascular disease. However, their review of this nascent literature was unbalanced, and we must challenge certain of their statements of “fact”.The “positive” effect of UA claimed by Amaro et al must be balanced against established data suggesting a link between increasing serum UA and cardiovascular disease.2–4 This relationship remains true for the acute infarct period.4,5 We have previously shown4 that small increments in admission serum UA are associated with significantly worse 90-day outcome. However, their group have previously …