Angiogenesis Detected After Embolic Stroke in Rat Brain Using Magnetic Resonance T2*WI | Zendy

Guangliang Ding | Zendy; Quan Jiang | Zendy; Lian Li | Zendy; Li Zhang | Zendy; Zheng Gang Zhang | Zendy; Karyn A. Ledbetter | Zendy; Lakshman Gollapalli | Zendy; Swayamprava Panda | Zendy; Qingjiang Li | Zendy; James R. Ewing | Zendy; Michael Chopp | Zendy

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Angiogenesis Detected After Embolic Stroke in Rat Brain Using Magnetic Resonance T2*WI

Author(s) -

Guangliang Ding,

Quan Jiang,

Lian Li,

Li Zhang,

Zheng Gang Zhang,

Karyn A. Ledbetter,

Lakshman Gollapalli,

Swayamprava Panda,

Qingjiang Li,

James R. Ewing,

Michael Chopp

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.502146

Subject(s) - medicine , sildenafil , angiogenesis , stroke (engine) , ischemia , saline , magnetic resonance imaging , embolism , embolic stroke , anesthesia , cardiology , ischemic stroke , radiology , mechanical engineering , engineering

This study uses T(2)* weighted imaging (T2*WI) to measure the temporal evolution of cerebral angiogenesis in rats subjected to embolic stroke up to 6 weeks after stroke onset with or without sildenafil treatment. Method- Male Wistar rats were subjected to embolic stroke and treated with saline (n=10) or with sildenafil (n=11), with treatment initiated at 24 hours and continued daily for 7 days after onset of ischemia. T2*WI measurements were performed at 24 hours after embolization and weekly up to 6 weeks using a 7-Tesla system. Histological measurements were obtained at 6 weeks after MRI scans.

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