Nitric Oxide Modulates Spreading Depolarization Threshold in the Human and Rodent Cortex | Zendy

Gabor C. Petzold | Zendy; Stephan Haack | Zendy; Oliver von Bohlen und Halbach | Zendy; Josef Priller | Zendy; ThomasNicolas Lehmann | Zendy; Uwe Heinemann | Zendy; Ulrich Dirnagl | Zendy; Jens P. Dreier | Zendy

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Nitric Oxide Modulates Spreading Depolarization Threshold in the Human and Rodent Cortex

Author(s) -

Gabor C. Petzold,

Stephan Haack,

Oliver von Bohlen und Halbach,

Josef Priller,

ThomasNicolas Lehmann,

Uwe Heinemann,

Ulrich Dirnagl,

Jens P. Dreier

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.500710

Subject(s) - cortical spreading depression , medicine , extracellular , in vivo , pathogenesis , nitric oxide synthase , subarachnoid hemorrhage , nitric oxide , depolarization , ischemia , anesthesia , neuroscience , biology , biochemistry , migraine , microbiology and biotechnology

Recent clinical data have suggested that prolonged cortical spreading depolarizations (CSDs) contribute to the pathogenesis of delayed ischemic neurologic deficits after subarachnoid hemorrhage. Elevated extracellular potassium concentrations and lowered nitric oxide (NO) levels have been detected in experimental and clinical subarachnoid hemorrhage. We investigated whether a similar extracellular composition renders the brain more susceptible to CSDs.

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