Involvement of Mitogen-Activated Protein Kinase Signaling in Growth and Rupture of Human Intracranial Aneurysms | Zendy

Elisa Laaksamo | Zendy; Riikka Tulamo | Zendy; Marc Baumann | Zendy; Reza Dashti | Zendy; Juha Hernesniemi | Zendy; Seppo Juvela | Zendy; Mika Niemelä | Zendy; Aki Laakso | Zendy

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Involvement of Mitogen-Activated Protein Kinase Signaling in Growth and Rupture of Human Intracranial Aneurysms

Author(s) -

Elisa Laaksamo,

Riikka Tulamo,

Marc Baumann,

Reza Dashti,

Juha Hernesniemi,

Seppo Juvela,

Mika Niemelä,

Aki Laakso

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.497875

Subject(s) - phosphorylation , p38 mitogen activated protein kinases , kinase , mitogen activated protein kinase , protein kinase a , signal transduction , microbiology and biotechnology , medicine , mapk/erk pathway , cancer research , biology

Mitogen-activated protein kinases (MAPKs) are involved in vascular wall remodeling, but their role in the pathogenesis of intracranial aneurysms (IAs) is poorly known. We investigated the expression and phosphorylation of the 3 major mitogen-activated protein kinases, c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinase, in unruptured and ruptured human IAs.

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