Nortriptyline Protects Mitochondria and Reduces Cerebral Ischemia/Hypoxia Injury | Zendy

Wenhua Zhang | Zendy; Hongyan Wang | Zendy; Xin Wang | Zendy; Malini Narayanan | Zendy; Irina G. Stavrovskaya | Zendy; Bruce S. Kristal | Zendy; Robert M. Friedlander | Zendy

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Nortriptyline Protects Mitochondria and Reduces Cerebral Ischemia/Hypoxia Injury

Author(s) -

Wenhua Zhang,

Hongyan Wang,

Xin Wang,

Malini Narayanan,

Irina G. Stavrovskaya,

Bruce S. Kristal,

Robert M. Friedlander

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.496810

Subject(s) - nortriptyline , mitochondrial permeability transition pore , neuroprotection , medicine , ischemia , pharmacology , mitochondrion , anesthesia , programmed cell death , biology , apoptosis , biochemistry , amitriptyline

Nortriptyline, an antidepressant, was identified as a strong inhibitor of mitochondrial permeability transition by our screening of a library of 1040 drugs. Because mitochondrial permeability transition and consequent mitochondrial dysfunction have been implicated in acute neuronal death, we proposed to investigate the possible neuroprotective effects of nortriptyline in cerebral ischemia.

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