Identification of Variations in Blood-Brain Barrier Opening After Cerebral Ischemia by Dual Contrast-Enhanced Magnetic Resonance Imaging and T 1sat Measurements | Zendy

Tavarekere N. Nagaraja | Zendy; Kishor Karki | Zendy; James R. Ewing | Zendy; Richard L. Croxen | Zendy; Robert A. Knight | Zendy

Open Access

Identification of Variations in Blood-Brain Barrier Opening After Cerebral Ischemia by Dual Contrast-Enhanced Magnetic Resonance Imaging and T _1sat Measurements

Author(s) -

Tavarekere N. Nagaraja,

Kishor Karki,

James R. Ewing,

Richard L. Croxen,

Robert A. Knight

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.496059

Subject(s) - magnetic resonance imaging , medicine , blood–brain barrier , nuclear magnetic resonance , ischemia , magnetization transfer , in vivo , evans blue , cerebral blood flow , pathology , nuclear medicine , central nervous system , radiology , biology , physics , microbiology and biotechnology

Variations in blood-brain barrier (BBB) opening after ischemia have been suggested by some tracer and magnetization transfer studies, although direct in vivo proof is still lacking. Contrast-enhanced magnetic resonance imaging (MRI) is also often used to visualize BBB damage in stroke. We hypothesized that MR contrast agents of different sizes enhance differently when BBB openings vary in size and that magnetization transfer alterations, measured by T(1) in the presence of off-resonance radiofrequency saturation (T(1sat)), in these regions reflect such differences.

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