No Association of PLIN Polymorphisms With Hemorrhagic and Ischemic Stroke | Zendy

Weihua Song | Zendy; Jingzhou Chen | Zendy; Kai Sun | Zendy; Hui Yu | Zendy; Rutai Hui | Zendy

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No Association of PLIN Polymorphisms With Hemorrhagic and Ischemic Stroke

Author(s) -

Weihua Song,

Jingzhou Chen,

Kai Sun,

Hui Yu,

Rutai Hui

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.496026

Subject(s) - medicine , stroke (engine) , linkage disequilibrium , ischemic stroke , population , perilipin , haplotype , allele , gene , genetics , ischemia , biology , mechanical engineering , environmental health , adipose tissue , lipolysis , engineering

Perilipin is encoded by the gene PLIN and mediates lipid metabolism. Its upregulation has been linked to the formation of foam cells, rupture of atherosclerotic plaques, and perhaps acute coronary syndrome. We hypothesized that genetic variations in PLIN might contribute to the susceptibility to stroke. The hypothesis was tested in 2 case-control studies.

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