Delayed Treatment With Minocycline Ameliorates Neurologic Impairment Through Activated Microglia Expressing a High-Mobility Group Box1–Inhibiting Mechanism | Zendy

Kazuhide Hayakawa | Zendy; Kenichi Mishima | Zendy; Masanori Nozako | Zendy; Mai Hazekawa | Zendy; Shohei Mishima | Zendy; Masayuki Fujioka | Zendy; Kensuke Orito | Zendy; Nobuaki Egashira | Zendy; Katsunori Iwasaki | Zendy; Michihiro Fujiwara | Zendy

Open Access

Delayed Treatment With Minocycline Ameliorates Neurologic Impairment Through Activated Microglia Expressing a High-Mobility Group Box1–Inhibiting Mechanism

Author(s) -

Kazuhide Hayakawa,

Kenichi Mishima,

Masanori Nozako,

Mai Hazekawa,

Shohei Mishima,

Masayuki Fujioka,

Kensuke Orito,

Nobuaki Egashira,

Katsunori Iwasaki,

Michihiro Fujiwara

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.495820

Subject(s) - minocycline , medicine , microglia , immunostaining , ischemia , pharmacology , anesthesia , pathology , immunohistochemistry , inflammation , antibiotics , biology , biochemistry

Minocycline, a semisynthetic tetracycline antibiotic, has been reported to ameliorate brain injury and inhibit microglial activation after focal cerebral ischemia. However, the cerebroprotective mechanism of minocycline remains unclear. In the present study, we investigated that mechanism of minocycline in a murine model of 4-hour middle cerebral artery (MCA) occlusion.

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