Open AccessAlbumin Therapy Improves Local Vascular Dynamics in a Rat Model of Primary Microvascular Thrombosis
Author(s) -
Anitha Nimmagadda,
HeePyoung Park,
Ricardo Prado,
Myron D. Ginsberg
Publication year - 2007
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.107.495598
Subject(s) - medicine , thrombosis , cardiology , albumin , vascular disease
High-dose human albumin is robustly neuroprotective in preclinical ischemia models and is currently in phase III clinical trial for acute ischemic stroke. To explore the hypothesis that albumin's protective effect is mediated in part by salutary intravascular mechanisms, we assessed microvascular hemodynamics in a model of laser-induced cortical arteriolar thrombosis.
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