Brain-Derived Neurotrophic Factor But Not Forced Arm Use Improves Long-Term Outcome After Photothrombotic Stroke and Transiently Upregulates Binding Densities of Excitatory Glutamate Receptors in the Rat Brain | Zendy

Harald D. Müller | Zendy; Kiran M. Hanumanthiah | Zendy; Kai Diederich | Zendy; Stefan Schwab | Zendy; WolfRüdiger Schäbitz | Zendy; Clemens Sommer | Zendy

Open Access

Brain-Derived Neurotrophic Factor But Not Forced Arm Use Improves Long-Term Outcome After Photothrombotic Stroke and Transiently Upregulates Binding Densities of Excitatory Glutamate Receptors in the Rat Brain

Author(s) -

Harald D. Müller,

Kiran M. Hanumanthiah,

Kai Diederich,

Stefan Schwab,

WolfRüdiger Schäbitz,

Clemens Sommer

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.495069

Subject(s) - medicine , brain derived neurotrophic factor , neurotrophic factors , ampa receptor , glutamate receptor , nmda receptor , ischemia , anesthesia , brain ischemia , endocrinology , stroke (engine) , saline , receptor , neuroscience , psychology , mechanical engineering , engineering

Both application of neurotrophic factors like brain-derived neurotrophic factor (BDNF) and constraint-induced movement therapy like forced arm use have been shown to potentially improve outcome after stroke. The aim of the present study was to check whether postischemic long-term outcome correlates to specific modifications in the abundance of various neurotransmitter receptors.

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