Inflammatory and Injury Responses to Ischemic Stroke in Obese Mice | Zendy

Satoshi Terao | Zendy; Gökhan Yılmaz | Zendy; Karen Y. Stokes | Zendy; Mami Ishikawa | Zendy; Takeshi Kawase | Zendy; D. Neil Granger | Zendy

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Inflammatory and Injury Responses to Ischemic Stroke in Obese Mice

Author(s) -

Satoshi Terao,

Gökhan Yılmaz,

Karen Y. Stokes,

Mami Ishikawa,

Takeshi Kawase,

D. Neil Granger

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.494542

Subject(s) - medicine , endocrinology , leptin , monocyte , ischemia , middle cerebral artery , reperfusion injury , stroke (engine) , obesity , mechanical engineering , engineering

Although epidemiological studies reveal an increased incidence of obesity and an association between obesity and the prevalence/severity of ischemic stroke, little is known about the mechanisms that link obesity to ischemic stroke. This study tested the hypothesis that obesity exacerbates the cerebrovascular dysfunction and tissue injury induced by brain ischemia and reperfusion.

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