Progressive Increase in Infarct Size, Neuroinflammation, and Cognitive Deficits in the Presence of High Levels of Amyloid | Zendy

Shawn N. Whitehead | Zendy; Guanliang Cheng | Zendy; Vladimir Hachinski | Zendy; David F. Cechetto | Zendy

Open Access

Progressive Increase in Infarct Size, Neuroinflammation, and Cognitive Deficits in the Presence of High Levels of Amyloid

Author(s) -

Shawn N. Whitehead,

Guanliang Cheng,

Vladimir Hachinski,

David F. Cechetto

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.492660

Subject(s) - medicine , neuroinflammation , cognition , stroke (engine) , amyloid (mycology) , cognitive decline , neuroscience , cardiology , pathology , inflammation , dementia , disease , psychiatry , mechanical engineering , engineering , biology

In the elderly, cerebral ischemia (CI) occurs in the presence of high levels of amyloid. Neuroinflammation plays a critical role in the pathophysiology of Alzheimer's disease and CI. This study examined infarct size, neuroinflammation, and cognitive deficits over time in rat models of Alzheimer's disease and CI.

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