Subcortical Lacunes Are Associated With Executive Dysfunction in Cognitively Normal Elderly | Zendy

Catherine L. Carey | Zendy; Joel H. Kramer | Zendy; S. Andrew Josephson | Zendy; Dan Mungas | Zendy; Bruce Reed | Zendy; Norbert Schuff | Zendy; Michael W. Weiner | Zendy; Helena C. Chui | Zendy

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Subcortical Lacunes Are Associated With Executive Dysfunction in Cognitively Normal Elderly

Author(s) -

Catherine L. Carey,

Joel H. Kramer,

S. Andrew Josephson,

Dan Mungas,

Bruce Reed,

Norbert Schuff,

Michael W. Weiner,

Helena C. Chui

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.491795

Subject(s) - medicine , episodic memory , executive dysfunction , hyperintensity , executive functions , neuropsychology , leukoaraiosis , cognition , cardiology , white matter , audiology , neuroscience , dementia , psychology , disease , psychiatry , magnetic resonance imaging , radiology

The relationship between subcortical ischemic vascular disease (SIVD) and cognition in normal elderly is unclear, in part because of methodological inconsistencies across studies. To clarify this relationship, the current study investigated a well characterized cognitively normal elderly sample (>or=55 years) with quantitative MRI and psychometrically robust neuropsychological measures within a multivariate model. Converging evidence suggests that SIVD selectively impairs frontal-executive tasks by disrupting frontal-subcortical circuits. We therefore hypothesized that MRI markers of SIVD would be selectively associated with worse executive functioning.

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