Polymorphisms in MMP Family and TIMP Genes and Carotid Artery Intima-Media Thickness
Author(s) -
Christine Armstrong,
Sònia Abilleira,
Matthias Sitzer,
Hugh S. Markus,
Steve Bevan
Publication year - 2007
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.107.491696
Subject(s) - medicine , population , intima media thickness , mmp3 , common carotid artery , mmp1 , cardiology , candidate gene , internal carotid artery , genetics , carotid arteries , gene , biology , gene expression , environmental health
Genetic variation in a number of MMP and TIMP genes have been implicated as risk factors for atherosclerosis, although such studies have been generally small and produced conflicting results. We have therefore sought to address this issue in a large, well-phenotyped community population to assess the effect of a number of polymorphisms in both MMP and TIMP genes on carotid artery intima-media thickness (IMT).
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