Effects of Initiation and Acute Withdrawal of Statins on the Neurovascular Coupling Mechanism in Healthy, Normocholesterolemic Humans | Zendy

Bernhard Rosengarten | Zendy; D. Auch | Zendy; Manfred Kaps | Zendy

Open Access

Effects of Initiation and Acute Withdrawal of Statins on the Neurovascular Coupling Mechanism in Healthy, Normocholesterolemic Humans

Author(s) -

Bernhard Rosengarten,

D. Auch,

Manfred Kaps

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.491423

Subject(s) - medicine , hemodynamics , discontinuation , nitric oxide , cerebral blood flow , anesthesia , blood pressure , statin , crossover study , placebo , cardiology , alternative medicine , pathology

Recent clinical trials imply increased risk of vascular events after statin withdrawal. There is evidence that this observation relates to an impaired nitric oxide system. The present analysis investigates the effect of initiation and withdrawal of statin therapy on resting and functionally activated cerebral hemodynamics in healthy young volunteers.

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