Spontaneously Hypertensive Rats Are Highly Vulnerable to AMPA-Induced Brain Lesions | Zendy

Clotilde Lecrux | Zendy; Olivier Nicole | Zendy; Laurent Chazalviel | Zendy; Christelle Catone | Zendy; Julien Chuquet | Zendy; Eric T. MacKenzie | Zendy; Omar Touzani | Zendy

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Spontaneously Hypertensive Rats Are Highly Vulnerable to AMPA-Induced Brain Lesions

Author(s) -

Clotilde Lecrux,

Olivier Nicole,

Laurent Chazalviel,

Christelle Catone,

Julien Chuquet,

Eric T. MacKenzie,

Omar Touzani

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.491126

Subject(s) - medicine , ampa receptor , stroke (engine) , neuroscience , cardiology , pharmacology , glutamate receptor , receptor , mechanical engineering , engineering , biology

Whereas the effects of chronic arterial hypertension on the cerebral vasculature have been widely studied, its effects on brain tissue have been studied less so. Here we examined if spontaneously hypertensive rats (SHRs) or the normotensive control Wistar Kyoto rats (WKYs) made hypertensive by renal artery stenosis (R-WKYs) are vulnerable to an excitotoxic brain lesion provoked by an overactivation of glutamate receptors.

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