Neuroprotective Effects of Adenosine Monophosphate- Activated Protein Kinase Inhibition and Gene Deletion in Stroke | Zendy

Jun Li | Zendy; Zhiyuan Zeng | Zendy; Benoı̂t Viollet | Zendy; Gabriele V. Ronnett | Zendy; Louise D. McCullough | Zendy

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Neuroprotective Effects of Adenosine Monophosphate- Activated Protein Kinase Inhibition and Gene Deletion in Stroke

Author(s) -

Jun Li,

Zhiyuan Zeng,

Benoı̂t Viollet,

Gabriele V. Ronnett,

Louise D. McCullough

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.490904

Subject(s) - ampk , neuroprotection , protein kinase a , medicine , amp activated protein kinase , adenosine , adenosine monophosphate , stroke (engine) , endocrinology , pharmacology , phosphorylation , microbiology and biotechnology , biology , mechanical engineering , engineering

5' adenosine monophosphate-dependent protein kinase (AMPK) acts as a metabolic sensor. AMPK is elevated under ischemic conditions, but the role of AMPK in ischemic brain remains controversial. In this study, we examined the effects of AMPK inhibition using both pharmacological and genetic approaches in an in vivo stroke model.

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