Hyperbaric Oxygen Reduces Tissue Hypoxia and Hypoxia-Inducible Factor-1α Expression in Focal Cerebral Ischemia | Zendy

Li Sun | Zendy; Hugo H. Marti | Zendy; Roland Veltkamp | Zendy

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Hyperbaric Oxygen Reduces Tissue Hypoxia and Hypoxia-Inducible Factor-1α Expression in Focal Cerebral Ischemia

Author(s) -

Li Sun,

Hugo H. Marti,

Roland Veltkamp

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.490599

Subject(s) - hyperoxia , medicine , ischemia , hypoxia (environmental) , middle cerebral artery , in situ hybridization , pathology , anesthesia , endocrinology , messenger rna , oxygen , biology , lung , chemistry , biochemistry , organic chemistry , gene

The usefulness of hyperbaric oxygen (HBO) and normobaric hyperoxia in acute ischemic stroke is being reexplored because both improve outcome in experimental cerebral ischemia. However, even the basic mechanisms underlying oxygen therapy are poorly understood. We investigated the effect of both oxygen therapies on tissue hypoxia and on the transcription factor hypoxia-inducible factor-1 alpha.

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